Effects of -lactam antibiotics on the gut microbiota: A study by Gu, S. Lolamicin

It’s the stuff of nightmares. Pathogens classified as Gram-negative bacteria are often hardy, virulent and quick to evolve resistance to antibiotics. Only a few drugs can knock them out, and these also destroy beneficial gut bacteria.

Lolamicin had anti-microbial effects against more than 130 multidrug-resistant strains of bacteria growing in laboratory dishes. Mice that developed blood stream infections after exposure to antibiotic-resistant bacteria all survived after being given lolamicin, whereas 87% of those that didn’t receive the compound died within three days.

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The Role of Clostridioides difficile colonization in Finding Antibiotics for Gram-negative Bacterial Viruses

Gitai says that the study “proves the viability” of targeting the Lol system, but adds, “There is a long road from showing efficacy in mice to developing a drug for human use.”

Hiller also sounds a cautious note. He says there is not much money to be made by a novel antibiotic when it is approved for clinical use in more than two decades. There are a number of new antibiotics that have been discovered but have not been approved by the US Food and Drug Administration.

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Source: A Gram-negative-selective antibiotic that spares the gut microbiome

Novel antibacterial targets based on the novel iclaprim/Staphylococcus aureus reductase inhibitor

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Source: A Gram-negative-selective antibiotic that spares the gut microbiome

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Source: A Gram-negative-selective antibiotic that spares the gut microbiome

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