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The human dopamine transporter has an interaction with cocaine

Characterization of a dopamine transporter from a fruit fly as novel atypical DAT inhibitors for the treatment of cocaine use disorders

Characterization of the dopamine transporter from a fruit fly. Cells 11, 3811 (2022).

Zou, M. F. et al. Structure–activity relationship studies on a series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes as novel atypical dopamine transporter (DAT) inhibitors for the treatment of cocaine use disorders. J. Med. Chem. 60, 10172–10187 (2017).

The article was titled “Osirim, A. V. et al.” Modifications to 1-(4-)(4-fluorophenyl)methyl)sulfinyl) alicyclic amines that improve metabolism and retain an atypical DAT player profile can be accomplished through these modifications. J. Med. Chem. https://doi.org/10.1021/acs.jmedchem.3c02037 (2024).

Nanobody-Binding Fab Module for Cryo-EM Studies of Human Serotonin Transporters and Other Membrane Proteins

J. S., Bloch, and other authors present their findings. Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc. Natl Acad. The USA 118, e2115431118 is in the same field.

Henry, L. K. et al. Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. It was the J. Biol. Chem. 281, 2012–2023 (2006).

Salomon, K. et al. Druggable potential with high-affinity allosteric inhibitors is revealed in the dynamics of human SERT. Proc. Natl Acad. USA 120, e2304089 120.

Cremona, M. L. et al. Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat. Neurosci. 14, 469–477 (2011).

Fog, J. U. et al. The amphetamine-induced reverse transport is regulated by the dopamine transporter C terminus. Neuron 51, 417–429 (2006).

Source: Structure of the human dopamine transporter in complex with cocaine

New class of amphiphiles bearing rigid hydrophobic groups and their applications to neurotransmitter substrate recognition and stabilization. Mol. Pharmacol. 28, 9485 – 9490 (2012)

P. S. Chae and others collaborated on a project. A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry 18, 9485–9490 (2012).

Przgen, Park, K., and Hirsh are all from the same area. The dopamine transporter is a primordial carrier for catecholamines. Mol. Pharmacol. 59, 83–95 (2001).

Loland, C. J. The use of LeuT is a model for studying binding sites for substrates and agents in neurotransmitters. There’s a relationship called a biochim. It is called biophys. Acta 1850, 500–510 (2015).

Borre, L., Andreassen, T. F., Shi, L., Weinstein, H. & Gether, U. The second site in the dopamine transporter is the cause of cation permeation. J. Biol. Chem. 289 was published in the year 2014.

Yamashita, A., Singh, S. K., Kawate, T., Jin, Y. & Gouaux, E. Crystal structure of a bacterial homologue of Na+/Cl−-dependent neurotransmitter transporters. Nature 437, 215–223 was published in 2005.

Nayak, S. R. et al. Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism. Nat. Struct. There is a journal called the Mol. Biol. 30, 1023–1032 (2023).

Source: Structure of the human dopamine transporter in complex with cocaine

Neuronal plasticity in response to inactivation of the human dopamine transporter in complex with cocaine: a new approach to psychostimulant abuse

The effects of neurotransmitters on the brains of patients with Parkinson’s disease. Int. J.Mol. is a science newspaper. Sci. 24, 15340 (2023).

Jones, R. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc. There was a Natl Acad. Sci. USA 95, 4029–4034 (1998).

Loland, C. J. et al. There is a potential drug for the treatment of psychostimulant abuse. There is a journal called Biol. Psychiatry 72, 405–411.

Source: Structure of the human dopamine transporter in complex with cocaine

Macromolecular crystallography with the LINCS linear constraint solver: application to the human dopamine transporter in complex with cocaine

Chen, V. B. MolProbity: all-atom structure validation for macromolecular crystallography. Crystallogr. The journal D. Biol. Crystallogr. 66, 12–21 (2010).

Hess, B., Bekker, H., Berendsen, H. J. C. & Fraaije, J. G. E. M. LINCS: a linear constraint solver for molecular simulations. J. Comput. Chem. 18, 1463–1472 (1997).

J. C. andShelley were involved. Epik is a software program for predicting the pKa of drug-like compounds. J Comput. Aided Mol. Des. 21, 694–693 in 2007.

OPM database and PPM web server resources for the positioning of the proteins in the human body. Nucleic Acids Res. 40, D370–D376 (2012).

Source: Structure of the human dopamine transporter in complex with cocaine

On the simulation of open MM, AMBER, and NAMD in the general force field of the charmm-Gui input generator

Vanommeslaeghe, K. et al. The general force field is a force field compatible with the CHARMM all-atom additive biological force fields. J. Comput. Chem. 31, 668–712.

Lee, J. The CHARMM-Gui input generator is used to produce simulations of OpenMM, AMBER, and NAMD. J. Chem. Theory Comput. 12, 405–413 (2016).

J. D. Impey and R.W. Comparison of simple functions for simulation of liquid water. J. Chem. 89, 92 and 93 were published in the year 1983.

Source: Structure of the human dopamine transporter in complex with cocaine

The human dopamine transporter is complex with cocaine. The Zenodo project at LEPII in Cologne (2001)

Nielsen, J. C. et al. The human dopamine transporter is complex with cocaine. Zenodo can be found on the web at http://www.zenodoro.org