The extinct woolly mammoth might be resuscitated with a 3D reconstruction of its genome
The Discovery of a Woolly Mammoth (Mammuthus primigenius) in Siberian Permafrost
Robert Fleischer, a senior scientist at the Center for the Preservation of the National Zoo in Washington, says that the prospect is exciting.
“If I was a 12-year-old in my science class in junior high school I’d probably think this was pretty cool,” Fleischer says. And I still believe it to be pretty cool.
The approach in the paper could help with the creation of a complete mammoth genome, according to the head of the biological sciences at Colos SAL Biosciences, which is working to resurrect the woolly mammoth.
“The preservation of genetic architectures from the woolly mammoth is really remarkable,” Flessa says. “But just because you can do it, doesn’t mean that it should be done. A genetically modified Asian elephant is not a wooly mammoth. And releasing such an animal into the wild would be arrogant and irresponsible.”
The science of bringing back the extinct pachyderm has been supported by Karl, a professor of geosciences at the University of Arizona.
Lynch says that there’s an enormous potential for consequences. Think about the other Invasives in the world. Until it gets to the environment, you don’t know the effect species will have on it.
But Lynch isn’t a fan of trying to bring back the mammoth. He says that the consequences of that could be disastrous. The money spent on the elephants would be better spent on something that would save them.
The University at Buffalo has an associate professor of biological sciences who wasn’t involved in the research.
Challenging that assumption, Lieberman Aiden and his colleagues embarked on a nine-year-long search for well-preserved ancient samples, eventually finding nearly intact chromosomes in 52,000-year-old skin samples from a woolly mammoth (Mammuthus primigenius) unearthed from Siberian permafrost. The discovery “was just mind-blowing”, says study co-author Cynthia Pérez Estrada, a geneticist at Baylor College of Medicine.
“Initially we had embarrassingly bad ideas. I am a little embarrassed to admit it. We said that it looked like a piece of mammoth on eBay. Let’s try that.’ It’s kind of a little cringe, right, to tell you that. Ebay is not a good place to get samples.
The 3-Dimensional Structure of the DNA of a Mammoth Extinct Species and its Implications for Genome Restoration
It would be possible to see how the chromosomes of a living cell were shaped, and you could also get a deeper understanding of the genomes of ancient and extinct species.
But there’s only so much scientists could learn from snippets of DNA. So Aiden and his colleagues launched an international effort to try to recreate the three-dimensional structure of the DNA, including the chromosomes, of an extinct creature.
The ancient Egyptian mummies were found 40 years ago to have remnants of DNA from the distant past. It has since become evident that in many ancient remains the DNA is preserved.
“It’s exciting,” says Erez Lieberman Aiden, a professor of of molecular and human genetics and director of the Center for Genome Architecture at the Baylor College of Medicine in Houston. We think it will be very valuable.
It should give new insights into the biology of the creature that has sparked fascination. The researchers said that the work could aid attempts to breed a living version of the animal.
The accomplishment, described Thursday in the journal Cell, marks what is believed to be the first time scientists have been able to produce a multidimensional version of the genome of a complex extinct species.
The mammoth’s closest living relatives, the modern elephants, showed similarities in structure, but also differences in activity of genes that are involved in hair growth and cold adaptation.
The team’s experiments on freeze-dried beef jerky which was subjected to extreme tests, including being shot with a gun and run over with a car, confirmed the researchers’ theory: the jerky shattered like glass but it remained intact.
Vctor Moreno Mayar is not involved in the study, but he says it is impossible to think that ancient DNA will stay the same. He says it’s really cool seeing that it can.
The findings suggest that the potential for recovering ancient DNA extends beyond what was previously thought possible, as long as the conditions are ideal, Moreno Mayar says.