UM171 glues a CRL3–HDAC1/2 assembly to degrade corepressors

Our study used y1 ion-based technology for the extraction of TMT reporter ion intensities and the generation of mean-centred intensities. We also corrected the raw intensities by the isotopic distribution of each labelling (for example, TMT126 generates 91.8%, 7.9% and 0.3% of 126, 127 and 128 m/z ions, respectively). We also calculated the mean-centred intensities across samples (for example, relative intensities between sample and mean).