The MitoBrainMap: Systematic Review of Cognitive Deficits in Adult Mitochondrial Diseases, by Martin Picard

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The map, which the study’s authors dubbed the MitoBrainMap, is both technically impressive and conceptually ground-breaking, says a neuroscience professor at the Technical University of Munich.

The brain’s mitochondria are much more than that. “The biology of the brain, we know now, is deeply intertwined with the energetics of the brain,” says Martin Picard, a psychobiologist at Columbia University in New York City, and a co-author of the study. And the brain accounts for 20% of the human body’s energy usage2.

Wielding a tool typically used for woodworking, the study’s authors divided a slice of frozen human brain ― from by a 54-year-old donor who died of a heart attack ― into 703 tiny cubes. Each cube measured 3 × 3 × 3 millimetres, which is comparable to the size of the units that make up standard 3D images of the brain. “The most challenging part was having so many samples,” says Picard.

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Source: A human brain map of mitochondrial respiratory capacity and diversity

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Source: A human brain map of mitochondrial respiratory capacity and diversity

A human brain map of mitochondrial respiratory capacity and diversity: a report from Med 65 (2012-12-2014), J. E. et al

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Source: A human brain map of mitochondrial respiratory capacity and diversity

Cytoelectric coupling and brain energy inefficiency in temporal-lobe epilepsy: a human brain map of mitochondrial respiratory capacity and diversity

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Source: A human brain map of mitochondrial respiratory capacity and diversity

Unsupervised Removal of Systematic Background Noise in Single-Cell Experiments: Validity of Psychological Autopsy by DSM-III-R Diagnosis

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Source: A human brain map of mitochondrial respiratory capacity and diversity

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